Week 1 -- Buffalo Bills at Los Angeles Rams to open 2022 season; Denver Broncos at Seattle Seahawks on Monday Night Football - ESPN
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Thursday night football schedule: Bills-Rams kickoff 2022 NFL season
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2022 NFL schedule release: Bills-Rams kicks off regular season; complete Week 1 schedule; all 32 home openers
2022 NFL schedule release: Buffalo Bills at Los Angeles Rams in season opener, Russell Wilson returns to face Seattle Seahawks, Christmas Day triple-header, NFL News
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Bills 2022 Schedule Released: Buffalo's 17 Opponents, Game Dates - Sports Illustrated